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It also allows the discovery of pseudo-gRNAs that contain mismatches and have, therefore, lost their functionality.
In general, absorbable sutures first lose their tensile strength while retaining a large portion of their mass and the actual absorption of the suture mass happens sometime after the suture has lost their functionality in terms of tensile strength.
Comparing human and chimpanzee promoters sequences with those of cattle and mouse, suggests that in the case of Late genes some NF-κB-family related TFBS lost their functionality and were abandoned or reorganized during species evolution.
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Even though Alzheimer patients lose their functionality, they dont lose their pride and dignity, cautioned Herron.
Cryopreservation is one of the key enabling technologies for tissue engineering and regenerative medicine, which can provide reliable long-term storage of engineered tissues (ETs) without losing their functionality.
As a result, they may detach from the suspending micro-holes and lose their functionality [11, 12].
"There are an abundance of consumer devices with integrated WiFi that lose their functionality when WiFi isn't available," said Michael Gartnerberg, vice president of strategy and analysis at Interpret.
Old differentiated cells lose their functionality while stem and progenitor cells dedicated to generating new differentiated cells lose their regenerative capacity [ 5, 6].
Implications and future directions The fundamental goal of diabetes research is to determine why β-cells lose their functionality in individuals with diabetes.
Fluorescent opto-chemical sensors often lose their functionality as a result of irreversible binding of the sensing components, photobleaching of the fluorophore, leaching of the chemistry, and/or the denaturing of the tertiary structure for the binding receptor [ 73, 74].
In mitoptosis, mitochondria can fragment, losing their outer membrane and releasing their contents into the cytosol, thus losing their functionality, or suffer fragmentation of the inner membrane leaving only a dysfunctional outer husk (Mijaljica et al., 2010; Tinari et al., 2007).
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CEO of Professional Science Editing for Scientists @ prosciediting.com