Sentence examples for lost the checkpoint from inspiring English sources

A growth advantage will be conferred upon cells which have lost the checkpoint machinery that functions under mitotic stress conditions.

However, tumor cells that fail to respond to this feed-back loop might have lost the checkpoint controls that maintain an intact pathway or may have a deregulated pathway [ 1, 32].

His key source: a public relations guy who had worked for Sensormatic, lost the account and quickly took on Checkpoint as a client.

If BRCA-linked disease requires inactivation of check-point(s) followed by BRCA gene loss, then the tissue specificity of BRCA-linked disease might arise from a specific predisposition of the breast and ovarian epithelium to lose the function of such checkpoints.

Another rebel commander, Arafat Mahmoud, reached by Skype in northern Syria, said he suspected the Syrian Army was just trying to regroup after having lost many checkpoints in the north, not to mention huge chunks of the city of Aleppo and other urban centers.

Losing the ability to control cell cycle checkpoints induces abnormal genetic instability.

In agreement with the role of ATM in establishing the G1/S checkpoint arrest to prevent cells with damaged DNA from entering the S-phase, primary Ctrl fibroblasts effectively arrested at the G1/S boundary after IR, but once reprogrammed into hiPSCs lost this G1/S checkpoint arrest to regain it at the stage of hNPCs.

The pair apparently got lost, ending up at the checkpoint on Mogadishu's outskirts.

Both mutants maintained Mad1 kinetochore localization (Fig 3B and C), but strongly or entirely lost checkpoint activity (Fig 3D), despite being present at similar levels as wild-type Mad1 (Fig 3E).

Unlike the original Perfect Dark, every mission contains a single checkpoint at which the player may restart if Joanna is killed or loses beyond that checkpoint.

Checkpoint activity was lost in the Mad1-RLK/AAA mutant (Fig 1F), although kinetochore localization of Ark1, Bub1, Bub3 and Mad3 was preserved (Fig 1E, Supplementary Fig S1B) and although Mad1-RLK/AAA was present at normal levels (Fig 1G) and the Mad1 Mad2 interaction was intact (Fig 1H).