Sentence examples for lost promoter from inspiring English sources

We chose this gene because the methylation arrays had shown that it lost promoter methylation during spontaneous differentiation of Shef-1, and because it is known to be a TSG that is frequently hypermethylated in cancer (Figure S6) [23], [23].

In contrast, Sps7 which encodes only nts 1 to 683 and lacks one essential SP1 binding side, completely lost promoter functionality.

They had promised that the losing promoter would shave his head, quite a gamble for King, whose coiffure is his trademark.

Here, we provide evidence that hippo-mediated inhibition of YAP1 is lost upon promoter methylation of the RAS effector and hippo kinase scaffold RASSF1A.

For example, in Otsuka-Long-Evans-Tokushima fatty (OLETF) rats (which have lost the promoter and exons 1 and 2 of the CCKAR gene by mutation) and in CCKAR-knockout mice, meal size is increased compared with control animals with normally functioning CCKARs (3).

All attempts to isolate a stable, SV40-LT expressing epithelial cell line from WAP-T mice derived tumors were unsuccessful, as during first days in culture the cells progressively lost WAP-promoter dependent SV40-LT expression and acquired a fibroblastic phenotype, as also described by others [80].

It is known that H2A.Z is lost at promoters and is enriched at the centromere when mitosis begins in mouse trophoblast stem cells [ 11].

As shown in Figure 7C, BK driven MMP-9 promoter activity was totally lost in AP1 promoter mutant, thus indicating that AP-1 binding domain is required for MMP-9 promoter activation by BK in RBA-1 cells.

"I think that if we didn't make the rematch, me and [UFC CEO Lorenzo Fertitta] should probably lose our promoter's license," White revealed.

King could lose his promoter's license in several states, including Nevada and New York.

When stem cells differentiate, these genes may lose their promoter hypermethylation, which could allow the genes to become overexpressed.