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To minimize the potential impact of bias due to losses to follow-up, baseline demographics of all patients diagnosed with mild or moderate probable AD who began treatment between 1997 and 2002 were examined and lost observations were compared with those who stayed on therapy and were followed to the study endpoint.
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The total sample size is n=72, because four observations were lost.
Notably, as colony results are reported "as mean values of six hives" it is unclear how lost colonies or missing observations were substituted for.
Close-up images were planned during Pioneer 10's encounter with Io, but those observations were lost because of the high-radiation environment.
If a subject was lost to follow-up observations were censored from the date of the first scheduled visit that they failed to attend.
Relatively few observations were lost.
A simulation study identified that seriously biased estimates of the odds ratios were obtained when observations were lost during the follow-up based on missing of random mechanisms [ 19].
In a lecture published by the Lancet in 1836 Magendie comments: 'The existence of the cerebro-spinal fluid was long ago remarked by the ancient writers on medicine; but these observations were either lost or remained unnoticed you will find it mentioned now for the first time, and then in consequence of the experiments I had made upon the subject' [ 32].
The reason for this likely is that not every patient lost from observation was accounted for by the ART-LINC active follow-up programs (personal consultation with Drs. Braitstein and Brinkhof).
Observations were also censored at the midpoint between the previous observation and the cutoff point of the present observation if a participant was lost to follow-up.
These observations were perfectly accurate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com