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Injuries and disease to the central nervous system (CNS) are accompanied by severe consequences, as the adult CNS has very limited capacity to replace the lost neural cells.
Finally, our Singularity series explores how "hacking the brain" can restore lost neural abilities.
Recent progress in stem cell biology has opened up a new way to therapeutic strategies to replace lost neural cells by transplantation of neural stem cells (NSCs) in CNS injury and disease [3] [8].
These plaques lead to lost neural function and cognitive impairment [ 9– 11].
These characteristics of NSCs make them promising candidates for replacement of the lost neural cells in neurodegenerative disorders including stroke.
However, those approaches for stroke are limited to acute measures designed to restore perfusion and to protect ischemic cells from death in the acute phase, which are unable to replace damaged or lost neural cells [ 4].
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Moreover, neural stem/progenitor cells (NSPCs) derived from postnatal mouse SVZ express RAE-1 and the expression of RAE-1 is lost after neural differentiation.
The brains of those from the infected batch had lost fewer neural cells and boasted more anti-inflammatory molecules.
When ROCKs are suppressed in CCE cells, renewal properties are lost and neural differentiation control is disrupted, leading to generation of NPCs.
Currently, the effective way to replace neural tissue lost is through transplantation of neural stem cells (NSCs).
Clinically relevant molecules that modify the properties of neural stem and progenitor cells (termed neural precursor cells; NPCs) could well provide a foundation for regenerative strategies that aim to replace lost and damaged neural cell types in the injured CNS.
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