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Finally, lost in the considerable data on potential transporters, carriers and delivery systems it is an unfortunate realization that, at present, none of these approaches are efficacious in treating diseases that lay beyond the BBB.
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Does the human spirit gets lost in the pursuit and possession of considerable material wealth?
In parallel with this observation, it was reported that the EGF-STAT1 signaling pathway, which is active in normal esophageal epithelial cells, is lost in a considerable fraction of esophageal cancer; furthermore, loss of EGF-STAT1 signaling was found to correlate with a worse clinical outcome [ 10].
Second, due to the nonadditive nature of the mDCM, local topological considerations, which are lost in global metrics, have a considerable effect on output.
Therefore, a considerable number of chemokine genes might have been lost in fish after the divergence of fish and the lineage leading to aves and mammals.
Hence, if the beam is lost in an uncontrolled way, it can do considerable damage to the machine components, which would result in months of down time [see (18, 19) for further details].
If it continues to do so, it risks losing the considerable gains it made in the 2000 polls, when it captured nearly 30% of the vote, compared with about 35% for the Democratic Party, a strong critic of China.Mr Tung's proposed changes to the bill addressed key concerns raised by the legislation's opponents.
EMI downplayed the news but lost its considerable investment in the band's first album, more than $750,000, according to EMI executives.
While the Screen Actors Guild remains the major union representing actors who work in feature films, it lost considerable ground in the last year in television work, in large part because television producers did not want to risk starting new television series with a union that might go on strike.
This music is known for its blend of accordion-based conjunto and polka oompah beat, but ever since superstar Selena was murdered in 1995 the genre has lost considerable influence in the music industry.
"The upswing in industry has clearly lost considerable momentum in the past few months," Ralph Solveen, an economist at Commerzbank in Frankfurt, said in a note.
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