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Most of the lost genes are on chromosome 2, a replicon that encodes more accessory functions than chromosome 1.
The functional annotations of these lost genes are given in supplementary table S1, Supplementary Material online.
The lost genes are obtained by comparison of orthologs identified by orthoMCL between a strain and the reference strain H37Rv.
However, the global pattern of unitary gene loss in Poaceae genomes as well as the evolutionary fate of lost genes are still less-investigated and remain largely elusive.
As to the argument that the lost genes are randomly selected or under special selection, increasing evidence inclines to the view that loss of functionality can be a selective advantage in some specific situations [ 45].
For example, two separate studies found that the human specific nonprocessed pseudogenes or long-established lost genes are overrepresented in genes belonging to large gene families, such as olfactory receptor or zinc finger protein family [ 41, 42].
Similar(48)
All four loci of lost genes were flanked by the insertion sequence element IS481.
For example, could lost genes be fast evolving genes?
Intriguingly both lost genes were most likely located on human chromosome 19.
These lost genes were not found to be significantly enriched in any annotation using rice GOSlim terms.
The majority of the 49 lost genes were related to metabolism and the "C" categories (Energy production and conversion).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com