Sentence examples for lost differentiated from inspiring English sources

Pathologists often refer to tumors that have lost differentiated morphologic features [found in early lesions] as undifferentiated or poorly differentiated malignancies, implying that the tumor cells have lost properties characteristic of differentiated cell lineages.

In the process of tissue regeneration, there are two ways that the replacement of the lost differentiated cells can occur in response to injury and disease: by the proliferation of common differentiated cells and/or by the deployment of specialized stem/progenitor cells [ 82].

Two major obstacles remain to be overcome: (1) Hyaline cartilage in vitro often loses differentiated traits.

Urothelial cells lose differentiated and functional characteristics when propagated in vitro.

4) Long-term LNSC lines are problematic, as the lineages have different survival capabilities and often lose differentiated characteristics.

As a specific cell type loses differentiated characteristics, such as is seen in the development of cancer, it may also consequently lose responsiveness to TM1 function.

Recently it was shown that premalignant mammary epithelial cells exposed to senescent human fibroblasts in mice irreversibly lose differentiated properties, become invasive and undergo full malignant transformation (Parrinello et al., 2005).

The epithelium began to exfoliate in culture and within 4 days appeared to have lost its differentiated high-zone layers of keratinocytes.

Penguins have lost their differentiated flight feathers.

Early in culture the epithelium began to exfoliate losing its differentiated high-zone layers into the medium, maintaining only basal and few parabasal cells (mostly both p63 and CK-19 positive), which had remained attached to the specimen.

In the presence of IL-1ß, chondrocytes express less hypertrophic chondrocyte-specific markers and are thought to lose their differentiated chondrocyte phenotype [ 16].