In the long term, however, populations within this region might end up losing adaptive immunity.
Perhaps, but it has long since lost any adaptive value.
The reference strain N2 could have lost this adaptive thermophilic response after introduction to the stable temperature of the laboratory [ 45].
Many patients receiving AmBisome have lost their adaptive and innate immune defenses, so the role of intrinsic immune factors may be critical in protecting them against IAV (Moen et al., 2009).
These results suggest that the CCUG strain has successfully adapted in the sulphite mill, but loses its adaptive benefits when exposed to a moderately different set of conditions.
A critical fact is that small populations are at risk of losing their adaptive capacity because genetic drift constantly lowers genetic diversity.
We observed that catalase induction in stationary phase was lost meanwhile the adaptive response to peroxide was maintained in this mutant.
Importantly, we provide evidence here that atypical MBCs have lost two key adaptive immune B cell functions, namely the ability to signal through the BCR and to differentiate into ASCs.
Our results also support the hypothesis that horizontal trabeculae are lost principally by strain adaptive resorption, while vertical trabeculae may be lost due to perforation from microdamage resorption followed by rapid strain adaptive resorption of the remaining unloaded trabeculae.
The finding that high-fidelity genotypes of an RNA virus have lost some of their adaptive properties in mice constitutes a strong support of this hypothesis [35], [36].
