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Daughters of the ISCs retain the expression of the Snail gene escargot, but unlike the ISCs, have capacity for terminal differentiation, replacing a lost absorptive enterocyte or secretory enteroendocrine cell (Potten, 1998), through largely unknown mechanisms.
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Combined with the histopathological picture, altered gut permeability and the significant drop in body weight in HLA-DR3.IFN-γ+/+ transgenic mice with time, it could be interpreted that there is a permanent damage to the gut epithelium as a result of which the absorptive functions of the epithelium is completely lost.
The intestine has a large reserve capacity for digestion and absorption of nutrients which is due to both excess function and to adaptive changes which increase function in one segment of the digestive-absorptive system when it is decreased or lost in another segment.
Gets lost.
Unlike control mice, Brd4-depleted animals continued to lose weight, owing to an inability to restore the absorptive epithelia, and most animals had to be sacrificed.
"I lose, lose, lose".
Lowered excretion indicates diminished intestinal absorption usually caused by a decreased absorptive surface, infiltrative intestinal disease, or bacterial overgrowth.
Reduced absorption of Fe and Zn might have resulted from downregulation of the absorptive system.
Epithelium may be protective, absorptive, or secretory.
"She's like a lump at the bottom — this huge absorptive thing".
Reflective films are metallic; absorptive films have dyes, pigments or ceramics in them.
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