New York City's water supply enters the city through three tunnels, the loss of which would make the city uninhabitable.
Saudi Arabia and Iran, for example, see Syria as a battleground in their regional power struggle, the loss of which they believe could endanger their own regimes.
German taxpayers are liable for around €70bn of Greece's €240bn of official debt, the loss of which, they say, would be manageable.
And there were "Remember Penn Station," the loss of which started it all, and "Don't Wrong Wright," about an unwanted addition to the Guggenheim Museum.
Another is the meaning of the "youth" label, the loss of which for the Times's Richard Morrison has meant the Bolívar "story is old hat".
He also allowed UNITA to have bases in Congo the loss of which could mark the end of UNITA as a fighting force after more than 30 years.
The next to go is taste, the loss of which is preceded by ravenous, animalistic bingeing on whatever is at hand.
"Given the grounds on which state aid was granted, and the current tender for the new Post Office card account, the loss of which could devastate the network, we believe this needs further consideration".
Mayor Michael Bloomberg wants a state judge to deny a union request to reinstate the checkoff, the loss of which has cost the union more than $1 million so far.
The sale of its assets may provide short-term cash, but it will deprive future generations of revenue and access, the loss of which has already happened in woods sold off.
However, the five villages, which are little more than farming hamlets, are the closest area of Isis influence to the famed archeological site, the loss of which for a second time has stung the regime of Bashar al-Assad.
