Sentence examples for loss of the functionality from inspiring English sources

Loss of the functionality of the GTPase cycle would have led to a relaxation of selective pressure on the G domain in terms of GTP/GDP discrimination, but continued selection for aa-tRNA-binding capabilities, resulting in an aSelBL that retains the classical GTPase fold.

This unstable glutathione thioester can subsequently be hydrolyzed leading to loss of the thioester functionality.

The neuronal loss, which can be as high as approximately 70%, is accompanied by the loss of the physiologic functionality of the dopaminergic system, leading to the emergence of severe motor symptoms, such as bradykinesia, muscular rigidity and resting tremor.

Since the refolding procedure that is required to obtain disulfide containing proteins in their native state can lead to loss of the thioester functionality, NCL is typically performed directly on the immobilized fusion protein to yield a stable amide bond, followed by refolding in redox buffer systems [ 18, 19].

The diminution of the fiber tracts was relevant to the loss of functionality of the PMG-affected cortex.

Surprisingly, despite the great age of the Poaceae and Cyperaceae transfers (and of the apparent loss of functionality of the original mitochondrial rps14 genes), nearly intact and expressed pseudogenes of rps14 have persisted in the mitochondrial genomes of most lineages of the two families.

After SC injury, neurological recovery depends mainly on the extent of neuronal loss and the functionality of the residual neural tissue.

The NTSB further added the following contributing factors: Contributing to this accident was the undetected loss of functionality of the airborne collision avoidance system technology as a result of the inadvertent inactivation of the transponder on board N600XL.

The combined action and further accumulation of both repeated mechanical loading and corrosion can aggravate the loss of functionality of the electrodes.

This class of mutations is functionally similar to nonsense point mutations that play a role in many cancers and might imply the loss of functionality of the 5' fused gene.

While commonly perceived as conferring a loss of functionality, the pseudo-motor domains have the ability to convert a kinesin-14 into a processive motor and additionally create functional diversity through allowing differential interactions with partners.