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Differing from sociologists' emphasis on the mechanism of the social division of labor on social solidarity at the end of the nineteenth century, this time the background is mainly the second modernity of individualization, i.e., the loss of the effectiveness of "modern" social institutions such as marriage and community (Komter and Vollebergh 2002).
Loss of the effectiveness of this drug compromises both the preventive therapy and treatment of TB disease.
In addition, impoverished pastoralists intensely depended on local natural resources, thus, they will return to their original ways of life resulting in the loss of the effectiveness of ecological management and the reverting of the ecological environment to a poorer state when the government compensation ends (Cao and others 2010; Beeton and Lynch 2012).
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The vaccine-resistant strain, in general, causes a loss of the protection effectiveness of vaccination [19], [20], [21], [22] (there is experimental evidence of the loss of the protection effectiveness for antiviral-resistant strains [23]).
Vaccine-resistant strains usually cause a loss of the protection effectiveness of vaccination.
Therefore, the loss of the protection effectiveness strongly impacts also on the optimal prevalence rate.
However, the vaccine-resistant strain causes a loss of the protection effectiveness of the vaccination [19], [20], [21], [22], [37].
Therefore, the loss of the protection effectiveness of vaccination plays an important role in preventing the spread of the disease.
The optimal prevalence rate is 84.6% when the loss of the protection effectiveness is between 0% and 5.6%.
We assume that the loss of the protection effectiveness is 35% (σ = 0.35: this value can be chosen arbitrarily with little effect on the meaning of the results).
We calculate the optimal prevalence rate, which depends on the loss of the protection effectiveness of the vaccination in Fig. 4 (sensitivity analyses are given in Supplementary Information: Text S1, Fig. S6).
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