Sentence examples for loss of stabilization from inspiring English sources

Mutations in SDHD result in loss of complex II function and are associated with loss of stabilization of HIF1 under normoxia and generation of reactive oxygen species [ 74].

Compared to the loss of stabilization, the additional loss of lateral inhibition results in a much faster dynamical process of lineage conversion.

As shown in Figure 4, addition of metal to D70A, E96A, D70A/E96A, or D308A proteins has no effect on the melting temperature, consistent with loss of stabilization by metal.

All three of these residues appear to be essential for stabilization of the enzyme by Mg2+ or Mn2+ measured by DSF, as substitution with Ala for any of these residues results in loss of stabilization.

These alterations could help to explain the previously reported cytoskeleton modifications induced by OA including cell rounding, loss of stabilization of focal adhesions, loss of barrier properties, and loss of cell polarity [ 56, 57, 108- 110].

OA causes loss of stabilization of focal adhesion and a loss of cytoskeletal organization, as a consequence of an alteration in the tyrosine-phosphorylation state of the focal adhesion kinases and paxillin (Romashko and Young, 2004).

In conclusion, bifurcation analysis reveals (1) that lateral stabilization accommodates multistability of the acinar and islet cell states, (2) that transient loss of lateral stabilization can cause the conversion of acinar to islet cells and (3) that concomitant suppression of lateral inhibition leads to direct conversion, bypassing the multipotent progenitor-like state.

Similarly, blocking EGFR activation in M sexta leads to fasciculation defects and axon stalling in the SZ, as well as to loss of neuroglian stabilization ([4; present study], thus also supporting a functional link between EGFR activation and neuroglian binding and stabilization.

Steric clashes, loss of electrostatic stabilization between an active-site arginine (Arg305) and the phosphonate analog, and a 180° flip of the hexose moiety account for the differences in the binding orientations of the isosteric phosphonate analog and the physiological substrate.

Using the technique of alternate fixation/permeabilization shown in Figure 10, we asked if blocking EGFR activation alone, without disrupting membrane subdomains, could lead to loss of neuroglian stabilization, as opposed to loss of expression.

This lack of sensitivity is consistent with the finding by Simizu et al. [23] that C-terminal PLK1 mutations in A549 (and in some other cell lines; see [23]) interfere with HSP90 binding and result in lower basal levels of PLK1, presumably via loss of the stabilization that would normally result from the binding of HSP90 to PLK1.