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These results of combined MISO and fractionated chemotherapy are in contrast to the rapid loss of sensitization observed when MISO is used as a radiation sensitizer and combined with small doses of X-rays, thus providing in vivo evidence of the mechanistic difference between the effects of MISO used as a radiation sensitizer or chemopotentiator.
Additionally, how can a supposed high allergen exposure convey loss of sensitization?
In addition, no loss of sensitization with increasing fractionation was observed when a lower dose of 0.2 mg g-1 MISO was combined with each of 5 or 10 daily fractions of CCNU.
Similar(57)
Three-hour hypoxic pretreatment with 5mM MISO significantly enhanced the subsequent response of 200 micrometers spheroids to heat at 43 degrees C. Oxic incubation at 37 degrees C between pretreatment and heating caused progressively loss of heat sensitization with time, recovery being almost complete after 6 h.
However, in combination with GSTP1, we found a strong effect modification of TNF G-308A, in that the risk of sensitization and loss of lung function following NOx exposure was greatest in children with GSTP1 Ile105Vand Val105Val and TNF GA/AA genotypes.
Studies involving healthy individuals and individuals with non-inflammatory pain syndromes (i.e., fibromyalgia) have identified two main mechanisms of widespread pain sensitivity: central sensitization and loss of diffuse noxious inhibitory control [ 46, 47].
The correlation between pericranial tenderness and short sleep duration, confirmed what we previously observed in adults, that the loss of sleep could facilitate central sensitization [8].
In addition to loss of descending analgesic activity, central sensitization may also alter pain processing among OA patients.
In addition to central augmentation of pain through central sensitization and/or loss of descending analgesia, functional neuroimaging studies suggest that structures in the medial pain system may modulate pain processing in RA.
In fibromyalgia, the importance of central nervous system pain mechanisms (for example, loss of descending analgesic activity and central sensitization) is well documented.
This diffuse hyperalgesic state of central augmentation of pain processing has been repeatedly identified using functional neuroimaging techniques [ 17, 18] and may partly be due to specific defects such as loss of descending analgesic activity and central sensitization.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com