Sentence examples for loss of requirement from inspiring English sources

Further, since transformed murine cells [28], tumor-derived human cells (shown here), and non-transformed mouse cells [28], [29], [30] all display this characteristic, the loss of requirement for de novo mRNA synthesis in late-G1 is independent of the species or transformation status of the cell.

This event was accompanied by the in vitro loss of requirement for exogenous growth factor(s) when tumorigenic TB6-3 cells were plated at high density.

Previous studies have shown that upon the introduction of Ras oncogene, MCF-10A cells undergo transformation and these transformed cells exhibit hall marks of transformation and epithelial-mesenchymal transition (EMT), including anchorage-independent growth, loss of requirement of hormones, invasiveness, and tumorigenicity in nude mice 36, 37.

Interestingly, it was suggested that bacterial PLCs might be descendants from eukaryotic PLCs that were incorporated by the bacteria during evolution and that the loss of requirement for a Ca2+ cofactor might have been evolutionary beneficial for bacteria living as intracellular parasites [ 150].

In common wheat, loss of vernalization requirement results in expression of early-flowering phenotypes [11].

One characteristic of cancer cells is the loss of this requirement, and such transformed cells gain the capacity to grow in an anchorage-independent manner [8].

We have already observed that loss of the requirement for signal-induced membrane binding prior to full scaffold activation leads to a decrease in the ultrasensitive nature of the signal response.

Along with the loss of the requirement for anchorage, a propensity for self-aggregation is a characteristic of aggressive cancer cells.

It is likely therefore that loss of a requirement for apomictic msp occurred very recently (or that the sequences have alternative functions strongly maintained by selection).

This data suggest that phosphorylated Stat3 has a role in regulating Cadherin expression and the loss of a requirement for cell-cell contacts in transformed cells.

Collectively, TP53, in addition to its role in orchestrating cell cycle arrest and apoptosis, counteracts the Warburg effect by favoring OXPHOS and minimizing glycolytic metabolism, and therefore its loss-of-function is a requirement for the aerobic glycolysis in most carcinogenic processes.