Sentence examples for loss of replication from inspiring English sources

Loss of ORCA could be causing either changes in replication timing of late-replicating regions or the complete loss of replication of these regions.

The rDEN3Δ30/31 virus showed a strong host range restriction phenotype with complete loss of replication in C6/36 mosquito cells despite robust replication in Vero cells.

The inhibitory action of the microbes may be attributed to the loss of replication ability of DNA upon treatment with the silver ion, besides the fact that expression of ribosomal sub-unit proteins as well as some other cellular proteins and enzymes essential to ATP production becomes inactivated [27].

These results show that the NUMT component of ARS1635 and ARS1215, and in particular the ACS motif, is essential for replication activity since its disruption is associated with the loss of replication activity of the entire region.

The deletion of DS results in a loss of oriP-specific binding of replication initiation proteins, which leads to an increased loss of replication competence in case of very small plasmids, but is tolerated in case of large EBV genomes [14], [15].

Although the high percentage of G+C in this sequence may involve a change in the helical stability of the DNA, we observed that the replacement of certain motifs was largely ineffective, indicating that the sequence itself is not responsible for the loss of replication activity.

In addition, frequent acquisitions and losses of replication origins might fundamentally alter the manner of genome replication, such as the development of a multiple-origin replicon from a single-origin replicon.

Thus, we proposed that the frequent reconstruction of the minichromosome might account for the variable replication origins in this replicon because independent gains and losses of replication origins accompanied the reconstruction processes.

This suggests that the cancer-related loss of asynchronous replication of SNRPN observed here resulted from delayed replication (due to cancer-mediated hypermethylation) of the normally early replicating paternal allele, rather than advanced replication of the normally late replicating maternal allele.

Parental histone recycling forms an attractive basis for maintaining histone modifications through replication (Corpet & Almouzni, 2009) and would be sensitive to loss of processive replication.

Nevertheless, given the fact that many independent mutations in different human ORC subunits, where some have been shown to affect replication functions directly, and hypomorphic mutations in the ATR replication check point protein lead to primordial dwarfism, it is hard to escape the inference that loss of ORC replication licensing functions are indeed epistatic to the MGS phenotype.