Phosphorylation of T18 resulted in some loss of helical propensity compared to that in unphosphorylated p53 and this largely seems to arise because of long range interactions between the phosphate and K24 that prevent helical propagation (Movie S10).
Generally, overgrowth due to the deviation from canonical cell cycle and/or loss of the propensity to undergo apoptosis are critical events in the development of cancer (Lowe and Lin, 2000; Sherr, 2000).
Chronic loss of Cdk5 increased the propensity for pharmacologically- and audiogenically-induced seizures.
The effect of Tip30 loss on the propensity of cell differentiation to ER+ mature luminal cells was likely mediated by the transcription factor FoxA1.
The economic dimension represents the propensity for loss of economic value due to physical damage or the loss of productive capacity.
Flow visualisation reveals the underlying flow structure within the roll-to-web transfer region and highlights when loss of stability, that is a propensity to streaking, occurs.
These overgrown masses of tissue exhibit characteristics of human cancers, including a failure to cease proliferation and differentiate, loss of tissue structure and a propensity to fuse and invade the surrounding tissues.
Since then, accumulated evidence has demonstrated its tumor-suppression role [ 2– 7], which was further enhanced by recent studies that showed downregulation or loss of maspin expression indicated greater propensity for metastasis and poor prognosis in patients, whereas upregulation of maspin is one of the independent factors for good prognosis [ 6– 9].
These include (1) the propensity for the evolutionary loss of sequence to encode D- or T-arms from tRNA genes, (2) a propensity for genome rearrangements, and (3) reduction in size of rRNA genes.
The social dimension represents the propensity for a loss of well-being, either individual (for example, mental or physical health) or collective (for example, services) and the characteristics of those most affected (for example, groups marginalized by virtue of race, ethnicity, or gender).
