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Increase or decrease of -OH groups in flavonoids would lead to loss of potent cytotoxicity [ 23].
This will clarify whether the observed change in activity of the fractions are due to loss of potent androgenic compounds during fractionation, too low bioassay sensitivity to observe activity in each fraction or to interactions between AR agonistic and AR antagonistic compounds.
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Yet something powerful disappeared with the end of steelmaking in Consett, and Redcar will now have to come to terms with the identity crisis created by the loss of so potent a symbol.
But this form of recycling in Scotland is set to come to an end, marking not just a cultural shift but the loss of a potent symbol – the empty ginger bottle – and the traditions that go with it.
Loss of Noggin, a potent BMP antagonist, leads to overgrowth of skeletal elements in mice [11].
Exclusion of timolol would thus mean the loss of a very potent and cheap IOP-lowering drug, and an increase in costs of glaucoma treatment.
PlcA, PPE and esx genes have all been shown to produce antigenic proteins [ 7- 9, 63- 65] and it is conceivable that the loss of such potentially potent antigens could aid in immune escape.
The ability of hMSCs for differentiation along several cell lineages is well known and depends on the tissue source, whereas a substantial loss of their multi-potent properties was observed during culture in vitro [ 7].
In Indonesia, where GDP is still below $5,000 a head, ordinary families will keenly feel the loss of fuel subsidies.More potent still in the emerging world are the political expectations of a rapidly growing middle class (see article).
In the earlier phases of the Cold War, before Britain had fully felt the loss of empire, the most potent symbols of betrayal were the real-life Cambridge spies who secretly worked for Moscow, notably Kim Philby, who inspired one of Mr. le Carré's most intriguing villains.
Loss of miR-29, a potent anti-fibrotic miRNA family that is regulated by TGF-ß and that targets multiple collagen species, is often associated with fibrosis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com