Induction by sophorose results in a loss of positioning of nucleosomes -1 and -2 downstream of the binding area, thus making the TATA box accessible.
Although deletion of Isw1 and Chd1 results in a loss of positioning of coding region nucleosomes, the nucleosome-free region and +1 nucleosome are largely unaffected (Gkikopoulos et al., 2011).
We find evidence mainly for the loss-of-position mechanism, but the rules of these games suggest that clock management likely also plays a role.
This causes abnormal sensation (numbness or tingling) or loss of sensation, loss of position sense and vibratory sense, and weakness of the muscles of the feet, lower legs, and hands.
What used to be a vibrant if fractious political debate, nourished, tolerated, and often exploited by the leadership, has turned into a dull and dismal discourse, steered by political directives, and driven by fear of suppression and the loss of position inside an ever-swelling bureaucracy.
The self-respect you gain far outweighs any temporary loss of position, power or income.
More profoundly, so has his loss of position, perks and deference.
With insufficient stability, there is a risk of loss of position, excessive motion, failure of union or consolidation and pain.
No cases of hardware failure, loss of position or alignment of fixed-angle locking screws, nervous complications, infection or allergy to the plate were observed in our cohort of patients.
In his memoirs, Khrushchev indicates he had pneumonia; some biographers have theorized that Khrushchev's illness was entirely political, out of fear that his loss of position was the first step towards downfall and demise.
