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Detailed pathology analysis of the early, non-proliferative intramucosal T1a lesions in prophylactic gastrectomy specimens of multiple family members with a c.1008G>T CDH1 germline mutation showed as the earliest, disease-initiating change reduced or absent expression of β-actin, p120 catenin, and Lin-7 compared to surrounding mucosa with general loss of organization of adherens junctions; [14].
In retinal cells, there was a severe loss of organization even though all the retinal cells were present (Fig. 7D).
This suggests a loss of organization since the LN-5 signal was detected around individual cell bodies in the rim and also within the multi-acinar structures (Fig 9Ae, g, h and i, arrows).
Their result to which we refer was near the distal end of the wing; they also show loss of organization proximally.
Studies on experimental models of ocular hypertension and human glaucoma evidenced astrocyte hypertrophy and loss of organization in both retina and optic nerve.
Compared to that of Patient A, the frequency spectrum of Patient B shows loss of organization, with greatly diminished H1 amplitude and the virtual absence of subsequent harmonic peaks.
Similar(52)
Cancer is a lethal disease characterized by uncontrolled cell growth, tumor formation, and loss of tissue organization.
Notable differences in collagen architecture and overall appearance were also observed in sham-treated aneurismal aortas compared with healthy and SA3N-treated groups, with profound loss of collagen organization and thick bundle formation.
These sheets could be readily transferred from patterned substrates to non-patterned substrates without the loss of tissue organization.
Lesion architecture was disrupted, with: i) loss of glandular organization, ii) reduced neovascularization, and iii) activation of caspase 3 in CD31+ endothelial cells.
Release of the gels resulted in a cell mediated gel contraction, an immediate loss of cytoskeletal organization, and an mRNA expression pattern similar to that seen with cytochalasin D treatment.
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