As much as it is about the quest for a miraculous being, "Unmistaken Child" is about Mr. Zopa's painful adjustment to the loss of a master he had served since the age of 7. His search is a crucial initiation ritual that restores meaning and purpose to a life that is suddenly desolate.
Finally, the loss of the master sequence obviously implies the loss of the information contained in it.
In any case, neither the delocalization beyond the error threshold nor the loss of the master sequence can be associated to a critical loss of information.
Our analyses provide evidence for the presence of a substantial subset of functionally important scaffold PSD proteins in the common ancestor of choanoflagellates and metazoans, and for secondary loss of the master scaffold protein Shank in placozoans.
This kind of threshold can induce the loss of the master type, i.e. a "wild-type threshold", or the delocalization over the whole sequence space, i.e. a "degradation threshold" [ 13].
Furthermore, both the loss of the master sequence and the delocalization of the quasispecies over the sequence space have been related to an information "crisis" or "meltdown" [ 6, 16, 26, 29, 30].
The so-called "information crisis" beyond the error threshold sometimes is associated to the loss of the master sequence [ 1, 26, 29], whereas in other cases it is associated to the delocalization over the whole sequence space [ 2].
In most papers the error catastrophe is equated to the loss of the master sequence [ 1, 17- 19], in other papers it is taken to be the delocalization of the population over the sequence space [ 20- 23], while in others it is defined as a transition to more robust regions of the sequence space [ 24].
These results are consistent with a phenomenon termed "error catastrophe" in which mutations accumulate with each cycle of infection in the presence of a VDA compound, eventually leading to the loss of the original master consensus sequence and the viral population's collapse [6], [7].
Metabolic disorders and inborn errors of metabolism like the various leukodystrophies usually present with the typical clinical history of a delayed/arrested development or with developmental regression characterized by a progressive loss of previously mastered developmental milestones.
