Sentence examples for loss of interactions from inspiring English sources

Therefore, LATS1 mutants (R657C, R694C and R697G) and LATS2 mutants (R623W and R645L), are expected to become inactive in human cancer due to loss of interactions with LATS activators such as MOB.

Since Φ-values calculated from molecular dynamics simulations are the same as those determined experimentally, we can, with confidence, use the molecular dynamics simulations to analyse the structure of the transition state in detail, and are able to show loss of interactions between the A′ and G-strands with associated A B and E F loops in the transition state.

As an example, cluster N-632 (Fig. 3C) illustrates a dioxin-dependent loss of interactions.

NFIX-CGGBP1 interaction is dependent on HMGN1, so the effects of HMGN1-siRNA could be due to the loss of interactions between NFIX and CGGBP1.

It can be suggested that in a disease protein network, loss of interactions around the hub over time could ankylose the network leading to its failure.

While loss of interactions between Domain 1 and β-helix are presumed to substantially change folding of the passenger domain, the effects of linker inserts in the protruding Domain 2 are most probably only local.

As in MEFs, the MUS81 loss-of-interaction mutants failed to interact with SLX4 in co-immunoprecipitation experiments (Fig. 2C).

Immunoprecipitation using FLAG-M2 agarose beads revealed loss-of-interaction with SLX4 compared with wild-type MUS81 (Fig. S3B).

Thus, we next wanted to test if MUS81−/− HCT116 cells complemented with MUS81 loss-of-interaction mutants were similarly defective in repair of ICL-induced DSBs.

The crystal structure shows a movement of Trp274 compared to the native, as a result of loss of interaction with the long side chain of Arg275.

This loss of interaction is relevant in vivo since we found that pol3-ct confers HU sensitivity on its own and synthetic lethality with a POL32 deletion.