Sentence examples for loss of interaction from inspiring English sources

Figure 4 figure supplement 2 actually shows the interacting fraction of EGFR with the PTB domain and a substantial loss of interaction is clearly visible in the perinuclear area that includes the RE.

This growth was accompanied by a much expanded mission and a loss of interaction with and focus on secondary education.

Deletion of the PWWP domain (LEDGF/p7593 530) resulted in a more diffuse nuclear distribution and a loss of interaction with condensed chromatin (Fig. 4B 66.

The loss of activity for a truncated RNF125 protein that contains the RING but not the C2HC ZnF/Li2120-128 region, correlated with a loss of interaction with 15N-UbcH5a seen by NMR (Fig. 4).

In comparison to the phosphorylated P21 structure (Supplementary Figure S8) additional zinc binding causes rotation of the Thr285 phosphoryl group and loss of interaction of His478 with the phosphoryl-oxygen.

This loss of interaction is relevant in vivo since we found that pol3-ct confers HU sensitivity on its own and synthetic lethality with a POL32 deletion.

The crystal structure shows a movement of Trp274 compared to the native, as a result of loss of interaction with the long side chain of Arg275.

The correlation between the loss of interaction of these KMTs with H3K4 (me3) and concomitant methylation impairment leads to the postulate that, at least these four KMTs, require stable interaction with their respective substrates for optimal activity.

As in MEFs, the MUS81 loss-of-interaction mutants failed to interact with SLX4 in co-immunoprecipitation experiments (Fig. 2C).

Immunoprecipitation using FLAG-M2 agarose beads revealed loss-of-interaction with SLX4 compared with wild-type MUS81 (Fig. S3B).

Thus, we next wanted to test if MUS81−/− HCT116 cells complemented with MUS81 loss-of-interaction mutants were similarly defective in repair of ICL-induced DSBs.