Sentence examples for loss of gene function from inspiring English sources

Gene loss can occur through either loss of gene function due to deleterious mutations or through complete deletion of the gene.

Loss of gene function could result from the insertion of T-DNA into functional gene sequences, or the T-DNA may have pleiotropic effects on the expression of other genes [6], [7].

Our study shows the utility of WES for identifying specific genetic conditions not clinically suspected and the importance of partial loss of gene function in ASDs.

The promoter methylation of the maspin gene leads to gene silencing in several tumors such as breast, thyroid, skin, and colon cancer and it has been recognized as one of the most frequent mechanisms causing loss of gene function.

Whole-exome sequencing has identified biallelic mutations in several genes previously associated with ASD (AMT, PEX7, SYNE1, APS13B, PAH, and POMGNT1) and demonstrated the importance of partial loss of gene function in this disorder [54].

DSBs trigger DNA repair mechanisms and can result in loss of gene function by error-prone non-homologous end joining (NHEJ), or they can be exploited to modify gene function or activity by precise homologous recombination (HR).

Loss of gene function can have dramatic fitness consequences for individuals.

Similar approaches to assay loss of gene function have been used successfully in zebrafish [19], [20].

In the 1990s, several related transgenic approaches to induce loss of gene function in plants were developed.

This epigenetic change results in no expression of tumour suppressor gene and plays a key role in an epigenetically mediated loss-of-gene function that is as critical for tumorigenesis as mutations in coding regions.

Silencing of the promoter region CpGs of regulated genes via hypermethylation is recognized as one of the mechanisms responsible for loss-of-gene-function in Knudson's two-hit tumor progression hypothesis[ 10].