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Decreased light availability, the loss of gap formation, a decrease in small-scale environmental heterogeneity and proliferation of strong competitors, all may have contributed to the observed decrease in species richness.
The subsequent overloading of cells with Ca2+ causes myocardial damage, loss of gap junctions, and impaired cell coupling [36].
All these factors can result from myocardial damage and in particular the loss of gap junctions, impaired cell coupling and myocardial heterogeneity which occur during Phase 1b and Phase 2 [36].
In contrast, loss of gap junctions increases intracellular signaling, leading to enhanced proliferation and tumor formation.
The loss of gap junctions is considered to be a critical step to prostate cancer progression (Mehta et al, 1999).
These findings suggest that the loss of gap junctions and Cx43 are associated with a neoplastic process [ 13, 14].
Similar(37)
Loss of connexin 43 does not, of course, directly prove a loss of gap-junction function.
When Sox17-null embryos were examined, the dyes did not migrate between cells, demonstrating a loss of gap-junction connections.
Gly21 is analogous to the Ras residue Gly12, which is often substituted in oncogenic Ras, and leads to loss of GAP-stimulated GTP hydrolysis (Leonardy et al, 2010).
Mutation of the cis-Gln in Ras, Rho and Ran, the trans-Gln in RabGAP or the trans-Asn in RapGAPs leads to a total loss of GAP-stimulated GTPase activity, stressing the importance of a properly located carboxamide side chain for catalysis of small G proteins.
No scales fell from my eyes, there was no sense of loss, of a gap in my life, etc. etc. Nor have I ever had any religious inklings.
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