Sentence examples for loss of functionally from inspiring English sources

The loss of functionally activating FcγRs will hinder this particular mechanism of deposition as shown in the present study as well as in experimental autoimmune myasthenia gravis.

Based on these data from DIV18 26, we conclude that apoE4 induces an early loss of functionally mature spines, compared with apoE2 and apoE3.

The relatively low amount of T-box regulation in these species could be the result of regressive evolution, a process that was suggested to be the underlying mechanism for the large loss of functionally active genes in S. thermophilus [ 54].

Age-related Macular Degeneration (AMD) is the most common cause of blindness in the developed world (Johnson et al., 2005).The disease usually affects patients in their seventh and eighth decades resulting in the loss of functionally important central vision.

Our results support that positive selection was likely involved in the functional differentiation of new copies of the OBP multigene family in the early stages after their birth by gene duplication; likewise, it might shape variation of some members of the family concomitantly with the loss of functionally related genes.

Indeed, positive selection was likely involved in the functional differentiation of new copies in the early stages after the gene duplication event; likewise, it might shape variation of some members of the family concomitantly with the loss of functionally related genes.

It has been suggested, however, that Ptc1 loss-of-function is not functionally equivalent to Smo activation in mammary epithelium, implying that Ptc1 might have Smo-independent functions in the gland [44], [45].

Indeed, it has been proposed that after WGD, duplicated genes can either accumulate loss-of-function mutations and are functionally lost (non-functionalization [ 3, 4]) or acquire a new function (neo-functionalization), or split the ancestral function between the paralogs (sub-functionalization) [ 2]), therefore adding complexity to the developmental gene network that shapes organ formation.

These are neoplasms that are all caused by loss-of-function mutations in molecules functionally classified as tumor-suppressor genes, and they are characterized by familial, juvenile or young onset and may be multicentric or bilateral.

Our observation that ΔN-Bcat expression co-operates functionally with loss-of-function mutations in Apc rather than gain-of-function Kras mutations implies the existence of a minimal threshold level for canonical Wnt/β-catenin signaling to trigger tumor formation (Roose et al., 1999; Samuel et al., 2009; Albuquerque et al., 2010; Buchert et al., 2010; Leedham et al., 2013).

In addition, 79 of 127 ubiquitously expressed genes which have been functionally characterized through loss-of-function studies belong to gene families (Jung et al. 2015).