loss of functionally

USAGE SUMMARY

The phrase "loss of functionally" is not correct; it should be "loss of functionality." You can use it when discussing a decrease or absence of the ability to perform a specific function, often in a technical or medical context.
Example: "The software update resulted in a loss of functionality, causing several features to become unusable."

⚠ May contain grammatical issues

Science

Human-verified examples from authoritative sources

Exact Expressions

8 human-written examples

The loss of functionally activating FcγRs will hinder this particular mechanism of deposition as shown in the present study as well as in experimental autoimmune myasthenia gravis.

Plosone

Based on these data from DIV18 26, we conclude that apoE4 induces an early loss of functionally mature spines, compared with apoE2 and apoE3.

ASN Neuro

The relatively low amount of T-box regulation in these species could be the result of regressive evolution, a process that was suggested to be the underlying mechanism for the large loss of functionally active genes in S. thermophilus [ 54].

BMC Genomics

Age-related Macular Degeneration (AMD) is the most common cause of blindness in the developed world (Johnson et al., 2005).The disease usually affects patients in their seventh and eighth decades resulting in the loss of functionally important central vision.

Biosensors and Bioelectronics

Our results support that positive selection was likely involved in the functional differentiation of new copies of the OBP multigene family in the early stages after their birth by gene duplication; likewise, it might shape variation of some members of the family concomitantly with the loss of functionally related genes.

BMC Evolutionary Biology

Indeed, positive selection was likely involved in the functional differentiation of new copies in the early stages after the gene duplication event; likewise, it might shape variation of some members of the family concomitantly with the loss of functionally related genes.

BMC Evolutionary Biology

Human-verified similar examples from authoritative sources

Similar Expressions

52 human-written examples

It has been suggested, however, that Ptc1 loss-of-function is not functionally equivalent to Smo activation in mammary epithelium, implying that Ptc1 might have Smo-independent functions in the gland [44], [45].

Plosone

Indeed, it has been proposed that after WGD, duplicated genes can either accumulate loss-of-function mutations and are functionally lost (non-functionalization [ 3, 4]) or acquire a new function (neo-functionalization), or split the ancestral function between the paralogs (sub-functionalization) [ 2]), therefore adding complexity to the developmental gene network that shapes organ formation.

BMC Evolutionary Biology

These are neoplasms that are all caused by loss-of-function mutations in molecules functionally classified as tumor-suppressor genes, and they are characterized by familial, juvenile or young onset and may be multicentric or bilateral.

BMC Cancer

Our observation that ΔN-Bcat expression co-operates functionally with loss-of-function mutations in Apc rather than gain-of-function Kras mutations implies the existence of a minimal threshold level for canonical Wnt/β-catenin signaling to trigger tumor formation (Roose et al., 1999; Samuel et al., 2009; Albuquerque et al., 2010; Buchert et al., 2010; Leedham et al., 2013).

DMM Disease Models and Mechanisms

In addition, 79 of 127 ubiquitously expressed genes which have been functionally characterized through loss-of-function studies belong to gene families (Jung et al. 2015).

Rice

Expert writing Tips

Best practice

When describing a decrease in functional capability, prefer using "loss of functionality" instead of "loss of functionally" for grammatical accuracy.

Common error

Avoid using the adverb "functionally" when the noun "functionality" is required. "Functionally" describes how something functions, while "functionality" refers to the ability to function.

Linguistic Context

The phrase "loss of functionally" attempts to describe a reduction or absence of a particular function. However, it is grammatically incorrect, as pointed out by Ludwig AI. The adverb "functionally" is misused in place of the noun "functionality."

Expression frequency: Uncommon

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Encyclopedias

0%

Ludwig's WRAP-UP

In summary, while the phrase "loss of functionally" appears in various scientific contexts, it is grammatically incorrect. As Ludwig AI points out, the correct phrase is "loss of functionality". The examples in Ludwig demonstrate the intended meaning, which relates to a reduction or absence of a particular function, typically in a technical or scientific domain. To ensure clarity and grammatical correctness, it's best to use "loss of functionality" or other alternatives like "functional loss".

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

loss of functionality

Replaces the adverb "functionally" with the noun "functionality" for grammatical correctness.

functional loss

Rearranges the words to create a more grammatically sound phrase.

impairment of function

Uses "impairment" to indicate a reduction in functional capability.

reduction in function

Replaces "loss" with "reduction" to convey a decrease in functionality.

decline in functional capacity

Uses "decline" and expands on the idea with "functional capacity".

loss of operational capability

Substitutes "operational capability" for a more specific context.

functional deficit

Uses "deficit" to indicate a lack or impairment of function.

deterioration of function

Emphasizes the gradual decline of functional abilities.

compromised function

Suggests the function is weakened or negatively affected.

dysfunction

A single word replacement that encapsulates the concept of impaired or abnormal function.

FAQs

What's the correct way to say there's a decrease in function?

The grammatically correct way to express a decrease in function is to use the phrase "loss of functionality" instead of "loss of functionally".

Can I use "functionally" to describe a loss?

No, "functionally" is an adverb and doesn't fit grammatically in the phrase "loss of functionally". The correct term is the noun "functionality", so use "loss of functionality".

What does "functional loss" mean?

"Functional loss" refers to the reduction or absence of a particular function or capability. It's a grammatically correct alternative to the incorrect phrase "loss of functionally".

How can I describe something not working as it should?

Instead of saying "loss of functionally", you can say there's an "impairment of function" or a "reduction in function" to accurately describe something not working as intended.