Sentence examples for loss of fad from inspiring English sources

The threshold for the selective loss of FAD fluorescence appeared ≤10% O2 in control mice (maintained at 37.0°C).

In contrast, hypoxia (≤15% O2) resulted in loss of FAD signal (i.e. increased reduced state of the FAD/FADH pool) except for a prominent preservation of signal in a ´halo´ around arteries/arterioles as seen in Figure 1.

Misfolding observed in these variants has been attributed to the loss of FAD anchoring, which has been reported to be crucial for folding and oligomerization (34).

The loss of FAD correlated with a loss of OhyA functionality, because enzymatic activity was restored to 80%% upon incubation of apo-OhyA with FAD (Table 1).

Little or no Nox4 DH domain-dependent activity was observed in the absence of added FAD, indicating loss of FAD during the purification.

The increase in activity of variant H103Y at 4 °C could be due to a loss of FAD cofactor upon freezing (after purification) and thawing incubation.

These findings strongly suggest that the overall mechanism of thermally induced inactivation of TvDAO and the ratio of the two major independent pathways of enzyme denaturation, partial loss of protein structure and release of FAD cofactor [ 22], were not altered by affinity-based immobilization of the oxidase.

Inactivation of the enzyme at 50°C was suggested to proceed via two main pathways: partial loss of protein structure leading to a denatured holoenzyme; and reversible release of FAD cofactor generating inactive apoenzyme.

Or, it could be the migration of the flavin- NH proton to the adjacent FAD OH, leading to loss of H2O and production of FAD.

A vigorous debate has been initiated over the issue of whether FAD PSEN alleles represent loss-of-function or gain-of-function mutations.

The inset of Figure 3 compares the time course of FAD release to the corresponding time course of fractional loss of enzyme activity in TvDAO immobilized on Sepabeads.