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The phrase "loss of efficacy" is correct and usable in written English.
It can be used in contexts discussing the reduction in effectiveness of a treatment, medication, or intervention.
Example: "The study revealed a significant loss of efficacy in the vaccine after six months."
Alternatives: "decrease in effectiveness" or "reduction in potency."
Exact(60)
There's a loss of efficacy, but the moral side grows".
"But," he said, "there is a potential loss of efficacy.
He added that any obstacles to a truck's spray range, including the wind, contribute to a loss of efficacy.
Loss of efficacy accounted for 63% of all treatment discontinuations.
An immune response comprised of neutralizing antibodies can lead to loss of efficacy or potentially more serious clinical sequelae.
This antibody response can, in some cases, lead to potentially serious side effects and/or loss of efficacy.
Ultimately, however, the secondary loss of efficacy of an anti-TNF-α drug will lead to a treatment switch regardless of the mechanisms responsible for such loss.
This uncertainty might be caused by the upcoming patent cliffs, production of cheaper generics, or loss of efficacy due to drug-resistance formation.
At baseline, 15 patients did not take any triptans because of contraindication, loss of efficacy, or because triptans had never been effective.
As Table 1 shows, there is no appreciable loss of efficacy between B. subtilis ATCC 6051 and B. pumilus SAFR-032 inactivation at 47 μg/mL.
This loss of efficacy of the model is due to a structural change in the American economy, whose potential rate of growth decreased in the late 1980s.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com