Differentiating HSPCs undergo progressive loss of differentiation capability in response to environmental conditions, resulting in terminally differentiated blood cells.
In the present study we found lower CTIP2 expression in more differentiated tumor type and CTIP2 expression increased with loss of differentiation.
Another point is that the stimulation of loss of differentiation state to generate iPSCs also involves epigenetics reprogramming process and differential expression of noncoding functional RNA (ncRNA).
Meanwhile, colon-specific enhancers lost the same histone mark, poising cells for loss of differentiation.
The loss of FGF-1 is consistent with loss of differentiation in dysplasias and some squamous cell carcinomas.
Whereas focal amplification of NKX2-1 in a fraction of human lung adenocarcinomas has focused attention on its oncogenic function, our data specifically link Nkx2-1 downregulatoon to loss of differentiation, enhanced tumour seeding ability and increased metastatic proclivity.
Knocking down of these genes resulted in a loss of differentiation ability.
CT evidence of cerebral edema was defined as a hypodense signal, effacement of the gray white matter junction, loss of differentiation of the lenticular nucleus and decreased visualization of the sulci, insula and cisterns [22].
This is in line with the continuous changes in morphology and loss of differentiation potential.
Loss of differentiation is thus an important characteristic of tumour cells and represents a defining feature of human cancers.
The authors concluded that concomitant loss of differentiation and acquisition of a wound-healing signature was associated with EMT.
