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Alzheimer's disease (AD) is a disease of the elderly marked by progressive loss of cognitive functioning.
Particularly the amount of slow-wave sleep (SWS) decreases with age and this decrease is paralleled by a loss of cognitive functioning in the elderly.
Also loss of cognitive functioning probably means that the patient becomes less able to perform ADL activities.
Dementia is the loss of cognitive functioning and memory, vascular dementia is due to many small strokes.
Our patient showed a very slow loss of cognitive functioning, this in the background of one major motor syndrome and an acute psychotic decompensation.
For example, the association of breast resection with feelings of loss of femininity [ 32, 33] may be viewed as analogous to the loss of cognitive functioning and identity seen with brain cancer.
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Obese, or overweight, older subjects with such presumed unimpaired longevity are nevertheless more likely to have hypertension and diabetes; develop coronary artery disease and possibly stroke; experience erectile dysfunction; suffer from accelerated loss of cognitive function, incontinence, frailty, osteoarthritis, and functional disability; and are dependent on others.
There is increasing evidence that, in addition to brain atrophy, aging and loss of cognitive function at high ages are associated with disrupted structural and functional brain connectivity.
As loss of cognitive function in Alzheimer's disease ultimately depends on loss of functional synapses (DeKosky and Scheff, 1990; Scheff et al., 1990) rather than on plaques themselves, we quantified the numbers of pre- and post-synapses as a readout to assess the efficacy of immunotherapy in a model of Alzheimer's disease.
In a fifth of cases, for example, lung cancer metastasises to the brain, inducing paralysis and loss of cognitive function: the patient, literally, loses their mind.
Alcohol contributes to the "geriatric giants", the four main health conditions that affect older people, they add, namely loss of cognitive function, immobility, instability and incontinence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com