Obese, or overweight, older subjects with such presumed unimpaired longevity are nevertheless more likely to have hypertension and diabetes; develop coronary artery disease and possibly stroke; experience erectile dysfunction; suffer from accelerated loss of cognitive function, incontinence, frailty, osteoarthritis, and functional disability; and are dependent on others.
There is increasing evidence that, in addition to brain atrophy, aging and loss of cognitive function at high ages are associated with disrupted structural and functional brain connectivity.
As loss of cognitive function in Alzheimer's disease ultimately depends on loss of functional synapses (DeKosky and Scheff, 1990; Scheff et al., 1990) rather than on plaques themselves, we quantified the numbers of pre- and post-synapses as a readout to assess the efficacy of immunotherapy in a model of Alzheimer's disease.
In a fifth of cases, for example, lung cancer metastasises to the brain, inducing paralysis and loss of cognitive function: the patient, literally, loses their mind.
Alcohol contributes to the "geriatric giants", the four main health conditions that affect older people, they add, namely loss of cognitive function, immobility, instability and incontinence.
Damage to the small blood vessels in the brain may explain the relationship that has been found between elevated homocysteine levels and the loss of cognitive function and Alzheimer's disease, say Dr. Jacob Selhub and colleagues at the United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University in Boston.
From this point, things get more disturbing: as the AI mines his mind's darkest recesses, we discover that Cooper's dad recently died from early onset Alzheimer's and his father's gradual loss of cognitive functions is what really terrifies our hero.
As the population continues to age, perhaps the greatest health benefit of regular physical activity will turn out to be its ability to prevent or delay the loss of cognitive functions.
Particularly the amount of slow-wave sleep (SWS) decreases with age and this decrease is paralleled by a loss of cognitive functioning in the elderly.
Alzheimer's disease (AD) is a disease of the elderly marked by progressive loss of cognitive functioning.
The disease is characterized by a gradual loss of cognitive functions, such as episodic memory.
