Sentence examples for loss of clock from inspiring English sources

However, loss of Clock significantly decreased the proliferation and increased the cell death of mESCs.

Indeed, we found that loss of Clock in mESCs triggered spontaneous differentiation.

Loss of Clock significantly decreased the proliferation and increased the cell death of mESCs indicated that Clock accurately regulated the development of mESCs.

After spontaneous differentiation, loss of CLOCK protein due to Clock gene silencing induced spontaneous differentiation of mESCs, indicating an exit from the pluripotent state, or its differentiating ability.

Loss of CLOCK protein due to Clock gene silencing in mESCs triggered their spontaneous differentiation, leading to stronger expression of genes in the three embryonic germ layers downstream.

This indicated that the nerve cells was very few in wild type mESCs and Clock knockout mESCs after spontaneous differentiation, so there wasn't compensation of NPAS2 for the loss of Clock (Fig. S3B).

It may also be informative to decrease clock gene copy number in a tetraploid background, to observe what possible circadian defects might arise from the loss of a clock gene following whole-genome duplication.

Beaver, L. M. et al. Loss of circadian clock function decreases reproductive fitness in males of Drosophila melanogaster.

However unlike the case of dORK, this was not correlated with a loss of molecular clock protein cycling [18].

The PERDKO mice showed loss of peripheral clock in the liver in animals maintained in a normal 24 hour light dark cycle, as evidenced by expression patterns of multiple core and output clock genes.

So far this question has been addressed by expression of dORK in LNv neurons [15] [16], which results in behavioral arrhythmicity in DD and loss of molecular clock protein cycling.