Sentence examples for loss of checkpoint function from inspiring English sources

The Bcl-6-mediated loss of checkpoint function may result in a potentially hazardous state of physiological genomic instability, which may cause B cells to undergo malignant transformation.

Loss of checkpoint function allows the cells to progress to mitosis despite the presence of damaged DNA, often resulting in mitotic cell death (MCD).

Since the promoter methylation of the CHFR gene was detected in non-invasive adenoma lesions of colon epithelia [44], the associated loss of the checkpoint function of CHFR in these cells may have a significant impact upon the early stages of colon carcinogenesis.

The reduction of the sensitivity to genotoxic agents closely links to loss of the checkpoint function that permits cells a high rate of genomic adaptation to acquire a growth advantage.

However, in EWSR1 siRNA transfected cells, Aurora B localized at the area between chromosomes and central spindle (Figure 8 D c and f), indicating a mislocalization of the CPC complex and potential loss of its checkpoint function.

Loss of BubR1 checkpoint function is lethal in the mouse [45], and biallelic BubR1 mutations are associated with childhood cancer and aneuploidy in humans [46].

Other studies have shown that cells with partial loss of the checkpoint function are resistant to microtubule destabilizing drugs such as nocodazole but not to microtubule stabilizing drugs such as Taxol.

Loss of p53 checkpoint function can lead to genomic instability and, in addition to the initiating virus-driven events, cervical carcinomas accumulate multiple genomic changes, of which only some are driver mutations for tumour development (Allen et al, 2000; Lando et al, 2009).

Perhaps loss of BRCA gene function in an otherwise intact epithelial cell might lead to its death or arrest, because of activation of checkpoint functions.

Chromosome instability can also be caused by loss of mitotic checkpoint functions, imperfections in kinetochore functions and centrosome amplification.

Others events can cause chromosome instability, such as loss of mitotic checkpoint functions, impaired kinetochore function and centrosome amplification.