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Disease in these kindreds tends to be more severe, with CM rapidly progressing to greater left ventricular hypertrophy, loss of cardiac function, and increased incidence of sudden cardiac death [9] [12], [14] [18].
Homozygous and double heterozygous transgenic mouse models of HCM have recapitulated increased disease severity and loss of cardiac function similar to phenotypes observed in humans [12], [18], [23], [24], [26] [28].
This loss of cardiac function is associated with a structural defect, consisting of reduced wall thickness and greater LV diameter.
Orai1 deficiency was found to exacerbate loss of cardiac function and hasten progression to dilation and was associated with increased apoptosis [ 63].
Interstitial fibrosis and fibrotic scar formation contribute to cardiac remodeling and loss of cardiac function in myocardial infarction (MI) and heart failure.
Interestingly, high levels of SIRT1 expression (>9-fold) in the heart causes hypertrophy, loss of cardiac function, and elevated apoptosis [ 1].
Similar(52)
Therefore, one benefit of loss of ankyrin-B-coupled Na/K ATPase is preservation of cardiac function under conditions of elevated afterload induced by hemodynamic stress.
Results from this study suggest that elevated circulating inflammatory cytokine such as IL-1β contributed to the cardiac contractile unit loss in diabetic heart, which takes responsibility for impairment of cardiac function.
Cardiac death occurs after irreversible cessation of cardiac function.
Second, "irreversible cessation" of cardiac function meant that at least five minutes had to pass without a heartbeat.
The measurement of cardiac output is a key element in the assessment of cardiac function.
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