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Although this has the disadvantage of losing interactions from some databases, we have found these losses to be relatively negligible.
Taken together these results indicate that the six broadly binding compounds along with earlier designs benefit from residing fully within the substrate envelope and thus decreasing the chance of losing interactions with a drug-resistant variant, rather than benefitting from an advantaged scaffold.
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With followings in the tens of millions, many Youtubers see no value in surrendering control of their content and losing interaction with their audience in exchange for a salary.
The sulphonamide, however, sits lower in the active site losing interaction with Asn434, and the pyrazole group rotates slightly to accommodate the larger moiety at the 3- position.
Several new NNRTIs incorporate flexibility in order to compensate for lost interactions with amino acid conferring mutations in RT.
Warren said the new work had taken account of the ability of species to migrate, but had not been able to include the impact of lost interactions between species as ranges contract, or of the impacts of more extreme weather events on wildlife.
Pooling often results in lost interactions for poorly understood reasons.
However, it contributes only little to restoring natural dynamics in the forest; ultimately, we need to release candidate ecological analogue species into the habitat in which we want to resurrect the lost interactions.
Melanoma cells must lose interactions with keratinocytes in order to invade the dermis.
Ribozymes must often be designed to incorporate debilitating substitutions to facilitate crystallization and, therefore, might lose interactions needed to properly position the active site.
The Q155N mutant quickly lost interactions with Asn195 and Ala194 at the helix 2 region, as indicated by the continuous increase in pairwise residue distances; however, the interactions between Asn155 and Glu159 were well conserved.
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