"From the moment a market becomes purely a vehicle for speculation, it loses its usefulness," the letter said.
If there are multiple CD4 determinations, the Track-shot rule can be used later on, but loses its usefulness once intra-individual variability makes it likely that an immediately retested CD4 count will reach the treatment threshold.
On the other side, a tool like a hammer may become "present-at-hand", when it breaks and loses its usefulness, or, at the first encounter, when we do not know how to interact with it.
But even for a trajectory defined with high precision by numerous points, this rule loses its usefulness once intra-individual variability makes it possible for the next point to reach the threshold (respectively below 430, 640, and 840 for the three thresholds at P = 0.05, and 370, 570, and 755 at P = 0.1).
As before, as CD4 counts come near to the decision threshold, this rule loses its usefulness and frequent CD4 monitoring becomes necessary.
The rule loses its usefulness in the presence of low to intermediate CD4 counts (below 550, 785, and 1000×106/L for the three respective decision thresholds at P = 0.05, and below 460, 675, and 880×106/L at P = 0.1).
"It has lost its usefulness as a focal center of high-level debate about Democratic policy".
But the tool has lost its usefulness.
Hon says the word "game" itself is rapidly losing its usefulness.
"You're welcome" took up its new function as an expression of rudeness at just the moment when the phrase lost its usefulness as a nicety.
The 48-hour debate ranged from whether the sport's showcase game could stand up without its showcase player, Pittsburgh's Sidney Crosby, to dismay over players who skipped the game for personal reasons, to whether the All-Star Game had lost its usefulness as a tool to promote hockey.
