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In this sense, the results in this area, as for instance [28 32], are improved, even for n = 2, where equation (1) loses its functional part.
For instance, after dioxin exposure, g3bp1 (GTPase activating protein (SH3 domain) binding protein 1) loses its functional coupling with chromosome replication genes mcm3, mcm4, and mcm5 (cluster N-63), but gains functional coupling with actin-associated genes cnn2 and arpc4 (cluster P-916) (Fig. 3B).
The sarcolemma loses its functional integrity, creating intracellular oedema and third-space loss, resulting in intravascular volume depletion, 15 which promotes homoeostatic activation of the renin angiotensin system, vasopressin and the sympathetic nervous system.
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It is possible that an anatomically intact ACL has already lost its functional role due to degenerative changes in the microstructure, as has been reported by Trompeter et al. [32], who showed that greater than two out of three ACLs found to be macroscopically normal during TKA present moderate-to-severe disease at microscopic assessment.
In many modern frame systems the vault has lost its functional significance and become a thin skin laid over a series of arches.
The AMEL gene mutations in these two bird species indicate that this crucial gene for enamel formation has lost its functional constrainsts long before the split between Passeriformes and Galliformes (Sire et al, unpublished data).
Previous work on mycobacterial PykA shows that in the absence of functional PykA, M. bovis loses its ability to use glycerol as carbon source [48].
In the presence of DSP, arterial endothelium lost its attachment and functional tests showed reduced dilation [ 29].
In eukaryotes, Krylov et al. [ 35] recently investigated the relation between the propensity of a gene to be lost and its functional importance.
After recombination becomes suppressed between a pair of proto-sex chromosomes, the Y undergoes a process of degeneration and loses most of its functional genes, due to a reduced efficacy of natural selection in a nonrecombining genomic region.
Losing half its functional width and forcing single lanes of traffic to zigzag slowly through town, it's as if town fathers wanted to be sure all would enjoy the modern and entertaining public art -- like the popular Chrome Buffalo, made of old car bumpers -- planted every few steps.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com