'lose its function' is correct and usable in written English.
You can use it when speaking or writing about something that has stopped working properly or is no longer able to do what it is supposed to. For example, "When the engine broke down, it quickly lost its function."
If after this the protein does not lose its function, then it is supposed that a frame shift has occurred in a functionally insignificant site or that the RF shift generates functionally similar amino acid sequences.
For example, KEAP1 is classified as an Act driver, although it is reported to lose its function upon mutation (Hayes and McMahon, 2009; Shibata et al., 2008).
The answer is that the informed consent may lose its function as a protection of personal autonomy if it is routinised.
It also forms a separate branch within clade II in the phylogenic tree, suggesting that it originated from another ancestral gene and is likely to lose its function as PPIase.
It is therefore important to understand how fast a protein can unfold or lose its function at high temperatures, such as near the water boiling point.
However, in order for pVHL to lose its function, biallelic VHL defects have to occur.
The gene duplication can create a new node which owns identical edges to the original node, but after being duplicated it could lose its functions (corresponding interaction edges are eliminated).
When the available energy of a node is less than a threshold level Eth, the node will lose its functioning.
Hence, it is hypothesized the water extraction of EBN may prevent human articular chondrocytes (HACs) lose its functions.
Meshed-e Sar, now called Bābol Sar, was formerly the port of Bābol on the Caspian, but it lost its function after the water level dropped.
However foam cushions are often squeezed by the repetitive thermal axial forces and the soil reactions, it loses its function to secure the expansion space of pipes.
