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Whereas Gla-less Gas6 seems to lose efficacy for Axl, removal of the Gla domain still reduces potency perhaps 20-50 ford for Mer and Tyro3.
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Many asthma medicines - Advair, for example [1]- begin to lose efficacy after being opened.
MOs are extremely effective through 50 hpf but can lose efficacy in a sequence-specific manner thereafter (see [ 4] for review).
They all lose efficacy over time.
These factors lose efficacy when gated neighborhoods are selected and surrounding facilities are distributed far away.
Antibodies developed during HIV-1 infection lose efficacy as the viral spike mutates.
The measurement result will finally lose efficacy due to these errors.
18 GHWL appear to lose efficacy with increased exposure.
Lyophilized PBAE nanoparticles can also be stored for years without losing efficacy and are easier to administer, as the user simply needs to add water and inject.
Bacteriophages could be suitable alternatives for antibiotics, which currently have lost efficacy because of the emergence of resistant strains.
While nanoparticles without added sucrose rapidly lost efficacy, nanoparticles formulated at 30 and 45 mg/mL sucrose maintained full efficacy for at least 2 years when stored at −20 °C.
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