Following cholestatic liver injury portal myofibroblasts loose expression of NTPDase2 allowing activation of basolateral P2Y receptors expressed by bile duct epithelia cells resulting in MAPK mediated proliferation of cholangiocytes [27].
Like LMNA (which is ranked third and will be discussed later) the rank of CD59/protectin means that these genes progressively loose expression of these probes.
Tumor cells often de-differentiate or have their origin in immature cell types and loose expression of proteins associated with highly differentiated cells, and could in stead gain expression of embryonic proteins.
After a cell has committed to the islet lineage by transactivating the endocrine marker Z, it looses expression of X.
Although Tregs therapy holds great promise, there is a major point to be considered: the stabilization of Foxp3 expression, since a fraction of expanded Tregs loose Foxp3 expression and consequently their suppressive potential.
MCF7-LTED, SUM44-LTED and HCC1428-LTED cells keep expression of ER, but T47D-LTED and ZR75-LTED loose ER expression.
As compared with human chondrocytes cultured without chitosan hydrogel which rapidly dedifferentiated in primary culture, cells mixed with chitosan rapidly loose the expression of type I and immature type II collagen while they expressed mature type II collagen and aggrecan.
This provides strong evidence, that these neurons were in fact lost and did not just loose YFP expression.
However, during differentiation of the trophoblast and the acquisition of an invasive phenotype trophoblast cells loose the expression of E-cadherin [16].
Despite retaining H3K27ac and H3K4me1 enrichment, these enhancers typically loose eRNA expression.
Along these lines, in our experimental system Msl1, or Nsl1 single, or double KD mESCs do not loose Oct4 expression, a common marker of mESC pluripotency.
