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The differences are even less comparing BAU-bound and 5-FU-bound enzymes, with structural differences limited almost exclusively to a loop lining the back side of the active site pocket (Figure 1, magenta highlight).
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Therefore, we inspected such protein modifications within the most flexible region of the nanopore lumen, with a focus on the large extracellular loops lining the central constriction.
These motions in turn drive axial movement of loops lining the hexamer pore (pore loops), which contain aromatic residues that directly engage substrate proteins during unfolding (Siddiqui et al., 2004; Iosefson et al., 2015).
This finding indicates that the local conformational reorganizations of the packing and flexibility of the fluctuating loops lining the central constriction of this protein nanopore were supplemented by changes in the single-channel kinetics.
A giant Andreas Gursky photograph of a racetrack in Bahrain traces black loops, lined by banners for Vodafone and the Royal Bank of Scotland.
a Fetal axial single-shot fast spin-echo MR image shows the bowel loops lined with peritoneal membranes (arrow) outside the abdominal cavity.
There are several good pubs here, and you can join the off-road greenway, which follows the former Loop Line railway back towards your starting point.
Using black figures on a white field, the loop lines up the icons of the usual monocultural suspects: Disney, Nike, Baby Bells, Texaco, Shell, McDonald's.
Then the work of stringing the overhead wires will begin and shortly afterwards the entire loop line from Slade Lane junction to Wilmslow will have been electrified.
Both groups get left behind and are forced to wait for the next train to crawl its agonisingly slow way along the Catford loop line and into the city.
The "while" loop (lines 20 39) reflects the actions in the AP and PP states.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com