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Loop formation is the rate-limiting step in this process.
Hou, C., Zhao, H., Tanimoto, K. & Dean, A. CTCF-dependent enhancer-blocking by alternative chromatin loop formation.
This result agrees well with an extrapolation from recent loop formation measurements in short synthetic peptides.
Prolines slightly disfavor His heme loop formation, presumably due to enhanced chain stiffness.
We propose a DNA extrusion model to account for orientation-specific loop formation.
At the base of the physical organizational structure of both is the concept of loop formation.
Similar(25)
TARID transcription, R-loop formation, DNA demethylation, and TCF21 expression proceed sequentially during the cell cycle.
S1-DRIP-seq identifies high expression and polyA tracts as major contributors to R-loop formation.
Ginno, P. A. et al. R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters.
Visser, M., Kayser, M. & Palstra, R. J. HERC2 rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long-range enhancer and the OCA2 promoter.
This scenario would be especially useful during gene transcription induced R-loop formation, which can result in single or double-strand breaks59.
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