Interestingly, stabilization of the β-turn within the cleavage loop accelerates self-cleavage, suggesting that small cyclic peptides may be tractable rational inhibitor starting points.
This effect is even smaller for P78A and is consistent with our hypothesis that the cis conformation of the R74 T80 loop accelerates autoproteolysis but indicates that it is not strictly necessary.
Like other recent reports, the new document says that runaway climate change cannot be ruled out, especially if the planet reaches a tipping point — for example, if melting Arctic permafrost starts releasing enough methane gas into the atmosphere to create a self-amplifying feedback loop of accelerating warming.
In later stages, migration may be reduced through ecological effects of selection resulting in a positive feedback loop of accelerating divergence [ 15].
The company is pursuing two goals: making innovative products with closed-loop credentials, accelerating the transition to a circular economy by establishing the business case for MacArthur's vision – and in that way, inspiring others to follow.
The feed-forward loops in accelerating transductions of signals have been extensively studied (Milo et al., 2002; Shen-Orr et al., 2002).
After performing a small loop, Andy accelerated northwest south of a subtropical ridge.
The data supports the existence of a negative feedback loop that accelerates aging by exacerbating proteostatic decline once misfolded and aggregation-prone proteins reach a critical level.
Our goal is a continuous feedback loop to accelerate the translation of data into knowledge from the basic sciences into the development of new treatments, translating the findings from clinical trials into everyday practice.
Activation of the alternative complement pathway triggers an amplification loop that accelerates cleavage of C3 to C3b, covalent binding to cellular surfaces, with release of the anaphylotoxin C3a and C5a, and formation of the complement membrane attack complex.
