This file can be used as an external feature lookup dataset.
Enrichment was assessed in R by means of Pearson's χ tests with Yates' continuity correction, testing for the difference in proportion of SNPs with association P < 0.05 in the lookup dataset according to association in the discovery dataset (P < 1 × 10−3 versus P ≥ 1 × 10−3).
However, as well as allowing simple gene-by-gene lookup, such datasets allow new insights to be synthesised by data mining.
To investigate whether statistical enrichment extended beyond genome-wide significant loci, we investigated the most significant (P < 1 × 10−3) independent (r < 0.2) endometriosis GWAS signals for enrichment of WHRadjBMI or BMI signals with P < 0.05 and vice versa (number of lookup SNPs per dataset: n = 717 to 748; see Supplementary Material, Methods).
For sake of this analysis, we performed the lookups using pseudo-random generated datasets containing 226 IP addresses and.
In order to investigate the effects of the input addresses on the performance, we performed the lookups using pseudo-random generated datasets containing 226 IP addresses with different matching ratios and the AS65000 prefix database.
These can be used to compare dataset intersection and exact lookup.
As depicted in Fig. 8, for each CPE configuration the algorithm attained similar lookup rates regardless of the prefix dataset.
Another major challenge is disk-chunk-index-lookup (keeping duplicated chunk indexes of large datasets creates memory overheads), which degrades the performance of backup clients due to frequently random I/O for lookup and indexing.
Likelihood lookup tables were computed for the total dataset and each arrangement separately, using independent estimates of the mutation rate parameter, θ, obtained from all noncoding sites as a prior (θTotal = 0.0134, θAR = 0.0064, θST = 0.0051, θPP = 0.0056, θTL = 0.0071, θCH = 0.0065).
Using a nickname lookup, a person recorded as Bill on one dataset and William on another could be given the same first name, potentially bringing these records together [ 18].
