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Although contradictory to the perceived image of a clinician always looking for differential diagnosis, this heuristic seems to provide an economical way of formulating a diagnosis or therapeutic plan.
We have taken the alternative approach of looking for differential expression between inbred lines of mice with different incubation times.
We identified cases of splice isoform separation by looking for differential conservation of MEHEs among gene duplicates.
We further investigate this hypothesis by looking for differential expression of members of this complex in datasets submitted to GEO.
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We looked for differential representation of taxa associated with individual cultivars or species.
As a measure of PPI-related brain activity, we looked for differential cerebral activation to prepulse-plus-pulse stimuli versus activation to pulse-alone stimuli.
To obtain insight into the biological significance of the evolutionary changes, we looked for differential trends between positively selected proximal promoters and proteins.
Using this strategy, we looked for differential gene expression in silenced cells using cDNA microarrays.
We looked for differential expression between the breast cancer subtypes using the standard approach of Welch's test.
For time-course experiments, we evaluated differential expression across multiple contrasts i.e. we looked for differential expression between any two of the time points in the experiment.
To complete the analysis of the differences between BM- and PL-MSCs we looked for differential splicing events between both sample types.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com