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Some of the depressive diathesis may arise through epigenetic mechanisms due to the ability of early life adversity to reduce (through methylation) expression of a glucocorticoid receptor gene promoter in the hippocampus, producing a longstanding reduction to glucocorticoid-mediated negative feedback inhibition of stress responses [ 27- 29].
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It is proud to be an early partner and supporter of the Food Recovery Network in addition to its other longstanding food-waste reduction efforts.
Those in Okinawa, the southern island province where most American troops are based, have stepped up their longstanding demands for a reduction in American forces.
The city's lawyers, Heidi Grossman and Linda Donahue, urged Judge Scheindlin to delay putting her ruling in place because the changes she ordered could create "an environment that may stem and reverse the longstanding record of crime reduction in this city".
Instead, they have abandoned longstanding party orthodoxy of deficit reduction and are seeking a political win after months of frustration on Capitol Hill.
Therefore, despite a drastic reduction in normal GR abundance, longstanding glucocorticoid excess may have deleterious effects through MR binding.
Reductions in working time have been a longstanding objective of trade unions.
And while increased detection of in situ tumors over the past two decades could theoretically result in later declines in invasive disease, if in situ tumors represent pre-invasive lesions, such a longstanding process is unlikely to account for the dramatic reductions seen over a 2-year period [ 51].
Senator Richard Durbin reverses longstanding positions in his support for the Simpson-Bowles deficit reduction plan spelled out in his op-ed in the Tribune.
This may reflect a gradual reduction in alcohol consumption to nondrinking with a longstanding illness over the time span, particular because previous LLI was associated with a cessation or reduction even ahead of the event occurring.
In one case report of a single patient, with longstanding DMO which was unresponsive to ranibizumab, Bertelmann and Shulze reported reduction in oedema and gain in visual acuity following a switch from ranibizumab to fluocinolone implant [ 16].
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