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When some longstanding patients drifted to other doctors, it felt bittersweet.
The most feasible explanation to this finding is that our cohort comprises mainly longstanding patients and aTNF were probably prescribed to those with more severe disease and higher Larsen scores at the beginning of the study (Table 1).
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A few weeks later the administrator of her school, a longstanding patient, mentioned how impressive it is that this woman continues to study despite having terminal cancer.
As seen in the previous study using biopsies from longstanding RA patients, the early RA patients could be divided into at least two different groups based on their gene expression profiles.
High expression of p53 was found in synovial tissue from longstanding RA patients and lower in early RA patients, osteoarthritis (OA) and reactive arthritis patients [ 45].
We detected AA-amyloid in longstanding AKU patients, confirming amyloidosis to be a progressive disease.
The same evidence, however, might limit the recommendations, as many studies were old and included longstanding RA patients who received methotrexate in low dosages without folic acid.
There are reports though of right atrial masses from organised clots or thrombus in longstanding haemodialysis patients dialysing via internal jugular semi-permanent catheters [ 5].
It has been reported that a low but constant capacity of regeneration of β-cells exists in longstanding T1D patients [ 3].
In this cohort of longstanding RA patients, the agreement between the AhFibA assay and the anti-CCP2 assay corresponded with the agreement observed in the RA patients of population 1.
In longstanding RA patients, we also found robust cytokine production in response to citrullinated fibrinogen-α 79 to 91, which was shown to be the immunodominant epitope in HLA-DR4-IE transgenic mice immunised with citrullinated human fibrinogen [ 15].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com