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Now, we present a collagen-based microstructured 3D nerve guide containing numerous longitudinal guidance channels with dimensions resembling natural endoneurial tubes.
Moreover, the closed-loop longitudinal guidance commands are computed on-board in a coupled way without relying on an explicit deceleration profile.
The main advantage of this approach is that the longitudinal guidance law is in-flight self-adaptive to any feasible hypersonic trajectory and can be written in analytical form with a small set of design parameters.
Our findings demonstrated that the O-CCH/PCL scaffold with uniform longitudinal guidance filler and a porous sheath exhibits favorable properties for clinical use and promotes nerve regeneration and functional recovery.
[ 25] Under sterile conditions, US dorsal longitudinal guidance was used for metacarpophalangeal and proximal interphalangeal biopsies.
This functionality promotes virtual co-management, whereby specialists provide longitudinal guidance to PCPs for patient management without the need for an in-person patient evaluation.
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Autografts are the current gold standard for peripheral nerve repair, as they provide abundant supporting cells for the regrowth of regenerated axons and offer intact intraluminal guidance along the longitudinal direction.
Such an NGC will not only provide longitudinal contact guidance for axonal extension but also deliver a wall robust enough to withstand the surgical operation.
The paper focuses on the longitudinal control and guidance aspects, with particular emphasis on the terrain-following problem.
The paper focuses on the lateral control and guidance aspects; longitudinal control aspects will be addressed separately in another paper.
The limited penetrance of defects found in many mutants affecting longitudinal navigation suggests that guidance cues act redundantly in this process.
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