Sentence examples for longevity model from inspiring English sources

Our hypothesis was that combining these two models would produce a super longevity model.

We demonstrated that AC5 disruption, that is, knock out (KO) mice, a longevity model, increases exercise performance.

One potential source for discovering novel molecular mechanisms that protect against malignancy is a longevity model, because a major cause of premature death in mice can be attributed to this disease process.

One of the targets uncovered, the mitochondrial antioxidant superoxide dismutase 2 (SOD2), has been linked to numerous longevity models.

Thus, the lower level of endogenous oxidative stress in these longevity models attenuates the ASK1-signalosome →p38 MAPK activity which favors longevity.

However, the transcription factor ATF4 is stabilized upon GCN2 activation and could be a key mediator in a variety of extended longevity models, including hypopituitary dwarf models and methionine restriction (Li et al., 2014).

In this study we analyzed mitochondria isolated from several tissues of young, middle-aged and old Ames dwarf and wild-type (WT) mice to identify whether the enzyme activities of ETC complexes CI-CV and the coupled CI-CIII and CII-CIII activities exhibit unique trends in activity that may distinguish between tissues of aging or longevity models.

For example, the insulin/IGF-1-like signaling (IIS) [1, 2, 3] is highly conserved to influence longevity in model organisms ranging from worms to mice [4].

Many of the genes that affect aging and longevity in model organisms, such as mice, fruit flies, and worms, have human homologs.

The mTOR pathway has been implicated in longevity in model organisms such as yeast, worms and flies.

SIRT1 is a NAD+ dependent deacetylase that is known to regulate caloric restriction mediated longevity in model organisms, and has also been linked to the insulin/IGF signaling pathway.